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Mannosidosis

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From Mannosidosis The Web Page

Skeletal problems:
The skeletal changes in patients with mannosidosis are frequent in occurence, sometimes disabling and not wholly explainable. It is especially seen in the spine of the chest which may give the patients a rigid and deformed spine and back pain. Further, a less acknowledged complication of the disease is the destruction of the joints, very much resembling the rheumatoid arthritis. The joints might be destroyed which together with ataxia may immobilise the patients. This has to be taken into account when planning housing and future jobs. This might occur at older age. Building programs for wheel-chair adapted houses equipped with elevator could secure the diseased an independent life. It is not clear to which degree orthopaedic surgery can help. In general there seems to be poor healing of the bone. Possibly less radical procedures should be considered whenever possible.